It takes a long time for a Degu to get used to being handled. It is not at all a natural thing, so they don't have built in instincts about being handled. (In the wild, humans don't normally befriend Degus, and certainly don't handle them.)
Because of that, enjoying being handled is a learned response, one that actually goes against all their built in instincts and reactions. Prey animals are notoriously nervous and "skittery".
Once you have scared your Degu, or hurt them, or teased them, it will then take even longer for them to learn to trust you. But I assure you it IS worth the time. It is unbelievably rewarding to earn the trust of these little ones.
There is good advice and good suggestions on this thread. If you are willing to dedicate a little bit of time everyday, you will earn their trust – because they are curious, social, and friendly little animals. I believe 100% that they do WANT to be our friends, it just goes against all their instincts, so they have to work hard to overcome those.
But I can vouch for them, they want to be our friends, they enjoy being with people, and they LOVE being handled, once they are used to it.
It is up to you if you want to put in the time and work, or if you’d rather give them away. But if you are willing to take it at their pace, it will be a MOST rewarding experience! There is nothing like having a Degu climb up your arm, sit on your shoulder, and give you kisses. Absolutely nothing!
If I lived close to you, I would come over and pick them up in a heart beat! Unfortunately, in Indiana, I don’t think that is a possibility.