My first rat died at home. He had respiratory issues and a mass in his abdomen. I waited too long and by the time I knew he was on his way out the vet couldn't fit me in right away to have him euthanized. I just sat with him and cried as he passed, in obvious pain. I won't go into detail. I have always regretted not taking action sooner.
In my opinion, when you know the end is coming it's best to think seriously about just letting go. You have to evaluate her quality of life. Is she still mostly happy? Is she still mostly comfortable? When the answers to those questions become "no" I believe that it's time. You know your rat and only you can answer those questions. It's obvious that you care deeply about her. Good luck.
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Six new rats