I hope the male babies are separated from the females by now. At 6 weeks they are old enough to get their sisters or Pearli pregnant.
As for Pearli, she wants to explore and have fun. Try getting her a playpen with a cover so that she can't climb out. The Marshall's small animal playpen is what I have, but the bar spacing is 1" and if she is very small she might be able to squeeze out. She should be supervised while in the pen, even if you think she can't get out.
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Six new rats