both my dogs get massively cars sick. They have since they were 12 weeks old. I have tried short trips, long trips, straight line trips, fun trips, trips without eating, trips with eating, trips a little bit cooler, trips a little bit warmer. I have tried dramamine, rescue remedy, a chamomile and lavender stress releaving spray and not a single thing has worked. I line the truck with a thick blanket and I bring a second one with me for the ride home. If they don't actually puke or poop then they will drool and look so awful it breaks my heart. So nope they stay at home the poor things, I take them to the vet once a year (of course unless I had an emergency) and anything extra that needs to be done that is none emergency I call in a mobile vet. I only use them for basic things like heartworming tests because it is off schedule from the regular vet vaccination schedule.