Snake faces take some getting used to, but once you are used to them, you can begin to read expression in their eyes (which do move, behind the clear scale that covers them), and in their attitude--posture, body language, etc. Once you can read their emotions, they seem just like any other animal.
Most snakes are shy animals. They are pretty defenseless, unless they have venom (most species don't have significant venom, and are harmless).
The average snake's bite is less serious than an attack by an overenthusiastic kitten (there's an animal with a vicious streak, lol).
Happily, the Eastern Indigo snake, a big, gorgeously iridescent purply-black snake that lives in the Everglades, is one of the species that may even benefit from the Burmese python presence. Indigo snakes prefer to dine on other snakes...baby Burms would make a great meal for them. The Burmese also eat raccoons, opossum, and other mid-level predators that like to dig up reptile eggs to eat. Bobcats were in decline, and these mid-level animals were growing in population, so in that respect, the Burms have temporarily stabilized things, and made it easier for turtles and other snakes to breed.
The report on how the pythons have been eating all of the mammals wasn't meant for release, by the way--it only notes a correlation, and not causation, and there are some anomalies that don't make sense if the Burms are responsible for the decline in mammals. The biggest one is the fact that numbers of rats increased, even as raccoons and opossums decreased. Rats are a favorite snake food, and even a big Burm will eat them, so why would their numbers go up?
I also think the idea that Burmese pythons in the everglades are responsible for declines in deer is hilarious...few snakes grow large enough to eat a deer, and in that marginal habitat, the largest snakes are the ones affected first in cold snaps, so there are even fewer of them.
Even if it were true (which is an absurdity), deer are overpopulated almost everywhere, due to a lack of large predators--the Florida panther is the only one they really have down there, apart from the occasional coyote taking a fawn, or alligator snatching one from the water's edge. There are definitely other, more plausible reasons for the declines...water pollution, invasive plants, overgrazing...etc.
The biggest threat to wildlife right now is habitat loss...the second, is invaders brought by humans...by which I mean, our companions, which accompany us wherever we go: rats, mice, cats, and dogs, hogs, and goats. One can only hope that the Burmese pythons that are keeping their toehold in the Everglades will develop a taste for piglet.
These guys eat everything--sea turtle eggs, alligator eggs, bird eggs and nestlings, roots, fruit, you name it...and they turn over the ground like a rototiller in the process. They're one of the worst invasive animals of all time.