I have a 33 gallon tank for my female mouse colony and that is a hassle dragging around the house to clean! I just use soap and water to clean it out.
You can use a vinegar and water solution or a water/bleach solution too to disinfect.
I use a spray (animal safe) called Holy Cow. It smells really good! And when it is getting stinky, I fill it with hot water and put the wheel and plastic hut in there with baking soda and sometimes vinegar. Takes the smell right out, which is amazing for the little buggers!